Assay Detail
Binding
CHEMBL858784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dopamine/serotonin receptor ligands. 10: SAR Studies on azecine-type dopamine receptor ligands by functional screening at human cloned D1, D2L, and D5 receptors with a microplate reader based calcium assay lead to a novel potent D1/D5 selective antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 44 | 6.97 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1204122 | — | — | 1 | 8.82 |
| CHEMBL201525 | — | — | 1 | 7.95 |
| CHEMBL382850 | — | — | 1 | 7.83 |
| CHEMBL201093 | — | — | 1 | 7.10 |
| CHEMBL201483 | — | — | 1 | 6.44 |
| CHEMBL201432 | — | — | 1 | 6.05 |
| CHEMBL1202298 | — | — | 1 | 5.97 |
| CHEMBL202924 | — | — | 1 | 5.58 |
| CHEMBL379450 | — | — | 1 | - |
| CHEMBL201288 | — | — | 1 | - |
| CHEMBL381573 | — | — | 1 | - |
| CHEMBL440390 | — | — | 1 | - |
| CHEMBL426662 | — | — | 1 | - |
| CHEMBL381102 | — | — | 1 | - |
| CHEMBL379673 | — | — | 1 | - |
| CHEMBL201142 | — | — | 1 | - |
| CHEMBL201177 | — | — | 1 | - |
| CHEMBL345349 | — | — | 1 | - |
| CHEMBL201287 | — | — | 1 | - |
| CHEMBL201577 | — | — | 1 | - |
| CHEMBL382780 | — | — | 1 | - |
| CHEMBL201575 | — | — | 1 | - |
| CHEMBL201086 | — | — | 1 | - |
| CHEMBL381912 | — | — | 1 | - |
| CHEMBL201748 | — | — | 1 | - |
| CHEMBL201444 | — | — | 1 | - |
| CHEMBL378358 | — | — | 1 | - |
| CHEMBL380484 | — | — | 1 | - |
| CHEMBL201334 | — | — | 1 | - |
| CHEMBL201241 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1204122 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL201525 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL382850 | — | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL201093 | — | Ki | = | 79.1 | nM | 7.10 |
| CHEMBL201483 | — | Ki | = | 361.0 | nM | 6.44 |
| CHEMBL201432 | — | Ki | = | 893.0 | nM | 6.05 |
| CHEMBL1202298 | — | Ki | = | 1078.0 | nM | 5.97 |
| CHEMBL202924 | — | Ki | = | 2610.0 | nM | 5.58 |
| CHEMBL201177 | — | Ki | - | — | - | |
| CHEMBL380124 | — | Ki | - | — | - | |
| CHEMBL345349 | — | Ki | - | — | - | |
| CHEMBL201287 | — | Ki | - | — | - | |
| CHEMBL201288 | — | Ki | - | — | - | |
| CHEMBL201010 | — | Ki | - | — | - | |
| CHEMBL383102 | — | Ki | - | — | - | |
| CHEMBL201598 | — | Ki | - | — | - | |
| CHEMBL201375 | — | Ki | - | — | - | |
| CHEMBL201788 | — | Ki | - | — | - | |
| CHEMBL437888 | — | Ki | - | — | - | |
| CHEMBL381325 | — | Ki | - | — | - | |
| CHEMBL201561 | — | Ki | - | — | - | |
| CHEMBL381472 | — | Ki | - | — | - | |
| CHEMBL382642 | — | Ki | - | — | - | |
| CHEMBL1398 | ALPHA-PHENYL-GAMMA-BUTYROLACTONE | Ki | - | — | - | |
| CHEMBL201739 | — | Ki | - | — | - | |
| CHEMBL201393 | — | Ki | - | — | - | |
| CHEMBL201575 | — | Ki | - | — | - | |
| CHEMBL201241 | — | Ki | - | — | - | |
| CHEMBL201334 | — | Ki | - | — | - | |
| CHEMBL380484 | — | Ki | - | — | - | |
| CHEMBL378358 | — | Ki | - | — | - | |
| CHEMBL201444 | — | Ki | - | — | - | |
| CHEMBL201748 | — | Ki | - | — | - | |
| CHEMBL381912 | — | Ki | - | — | - | |
| CHEMBL201086 | — | Ki | - | — | - | |
| CHEMBL201142 | — | Ki | - | — | - | |
| CHEMBL382780 | — | Ki | - | — | - | |
| CHEMBL201577 | — | Ki | - | — | - | |
| CHEMBL379450 | — | Ki | - | — | - | |
| CHEMBL381573 | — | Ki | - | — | - | |
| CHEMBL440390 | — | Ki | - | — | - | |
| CHEMBL426662 | — | Ki | - | — | - | |
| CHEMBL381102 | — | Ki | - | — | - | |
| CHEMBL379673 | — | Ki | - | — | - |