Assay Detail
Binding
CHEMBL858799
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Inhibitory activity against rabbit Cathepsin K
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.64 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201782 | — | — | 1 | 9.49 |
| CHEMBL201914 | — | — | 1 | 9.30 |
| CHEMBL383612 | — | — | 1 | 9.23 |
| CHEMBL371954 | — | — | 2 | 8.43 |
| CHEMBL370139 | — | — | 1 | 8.04 |
| CHEMBL202103 | — | — | 1 | 8.04 |
| CHEMBL427377 | — | — | 1 | - |
| CHEMBL381135 | — | — | 1 | - |
| CHEMBL201733 | — | — | 1 | - |
| CHEMBL202554 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201782 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL201914 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL383612 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL371954 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL370139 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL202103 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL371954 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL427377 | — | IC50 | - | — | - | |
| CHEMBL381135 | — | IC50 | - | — | - | |
| CHEMBL201733 | — | IC50 | - | — | - | |
| CHEMBL202554 | — | IC50 | - | — | - |