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Assay Detail

CHEMBL858930

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of 12-hLO
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Polyunsaturated fatty acid lipoxygenase ALOX12 (CHEMBL3687)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel human lipoxygenase inhibitors discovered using virtual screening with homology models.
Kenyon V, Chorny I, Carvajal WJ, Holman TR, Jacobson MP.
J Med Chem (2006) 49 : 1356 -1363
PubMed 16480270 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.71 4.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL381149 1 4.91
CHEMBL378602 1 4.51
CHEMBL202698 1 -
CHEMBL204926 1 -
CHEMBL204917 1 -
CHEMBL201368 1 -
CHEMBL370583 1 -
CHEMBL201969 1 -
CHEMBL202560 1 -
CHEMBL201191 1 -
CHEMBL202034 1 -
CHEMBL201812 1 -
CHEMBL202582 1 -
CHEMBL370234 1 -
CHEMBL383552 1 -
CHEMBL381113 1 -
CHEMBL202533 1 -
CHEMBL202366 1 -
CHEMBL383793 1 -
CHEMBL202482 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL381149 IC50 = 12300.0 nM 4.91
CHEMBL378602 IC50 = 30700.0 nM 4.51
CHEMBL202698 IC50 > 100000.0 nM -
CHEMBL204926 IC50 > 100000.0 nM -
CHEMBL204917 IC50 > 100000.0 nM -
CHEMBL201368 IC50 > 200000.0 nM -
CHEMBL370583 IC50 > 100000.0 nM -
CHEMBL201969 IC50 > 200000.0 nM -
CHEMBL202560 IC50 > 200000.0 nM -
CHEMBL201191 IC50 > 100000.0 nM -
CHEMBL202034 IC50 > 100000.0 nM -
CHEMBL201812 IC50 > 200000.0 nM -
CHEMBL202582 IC50 > 100000.0 nM -
CHEMBL370234 IC50 > 200000.0 nM -
CHEMBL383552 IC50 > 100000.0 nM -
CHEMBL381113 IC50 > 100000.0 nM -
CHEMBL202533 IC50 > 200000.0 nM -
CHEMBL202366 IC50 > 500000.0 nM -
CHEMBL383793 IC50 > 200000.0 nM -
CHEMBL202482 IC50 > 200000.0 nM -