Assay Detail
Functional
CHEMBL859000
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Growth inhibition in breast cancer MCF7 cell line by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Orally active purine-based inhibitors of the heat shock protein 90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.43 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201871 | — | — | 1 | 6.70 |
| CHEMBL199532 | — | — | 1 | 6.70 |
| CHEMBL381376 | — | — | 1 | 6.70 |
| CHEMBL201162 | — | — | 1 | 6.70 |
| CHEMBL381115 | — | — | 1 | 6.30 |
| CHEMBL381521 | — | — | 1 | 6.22 |
| CHEMBL191635 | — | — | 1 | 6.16 |
| CHEMBL193282 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201871 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL199532 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL381376 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL201162 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL381115 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL381521 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL191635 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL193282 | — | IC50 | = | 1200.0 | nM | 5.92 |