Assay Detail
Binding
CHEMBL859052
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Binding affinity to Bcl2 by fluorescence polarization assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 6.43 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198903 | — | — | 1 | 7.26 |
| CHEMBL201947 | — | — | 1 | 7.23 |
| CHEMBL192571 | — | — | 1 | 7.17 |
| CHEMBL380709 | — | — | 1 | 7.16 |
| CHEMBL370835 | — | — | 1 | 7.14 |
| CHEMBL379013 | — | — | 1 | 7.12 |
| CHEMBL380502 | — | — | 1 | 7.04 |
| CHEMBL202798 | — | — | 1 | 6.94 |
| CHEMBL383399 | — | — | 1 | 6.92 |
| CHEMBL370837 | — | — | 1 | 6.78 |
| CHEMBL383229 | — | — | 1 | 6.72 |
| CHEMBL370836 | — | — | 1 | 6.64 |
| CHEMBL382648 | — | — | 1 | 6.50 |
| CHEMBL201670 | — | — | 1 | 6.44 |
| CHEMBL382018 | — | — | 1 | 6.40 |
| CHEMBL204822 | — | — | 1 | 6.40 |
| CHEMBL371861 | — | — | 1 | 6.36 |
| CHEMBL434952 | — | — | 1 | 6.14 |
| CHEMBL378820 | — | — | 1 | 6.13 |
| CHEMBL380433 | — | — | 1 | 5.91 |
| CHEMBL379895 | — | — | 1 | 5.90 |
| CHEMBL372834 | — | — | 1 | 5.70 |
| CHEMBL202964 | — | — | 1 | 5.67 |
| CHEMBL202540 | — | — | 1 | 5.54 |
| CHEMBL378808 | — | — | 1 | 5.49 |
| CHEMBL203620 | — | — | 1 | 5.45 |
| CHEMBL201669 | — | — | 1 | 5.34 |
| CHEMBL382361 | — | — | 1 | - |
| CHEMBL202509 | — | — | 1 | - |
| CHEMBL204915 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198903 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL201947 | — | Ki | = | 58.8 | nM | 7.23 |
| CHEMBL192571 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL380709 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL370835 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL379013 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL380502 | — | Ki | = | 92.1 | nM | 7.04 |
| CHEMBL202798 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL383399 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL370837 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL383229 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL370836 | — | Ki | = | 231.0 | nM | 6.64 |
| CHEMBL382648 | — | Ki | = | 317.0 | nM | 6.50 |
| CHEMBL201670 | — | Ki | = | 366.0 | nM | 6.44 |
| CHEMBL382018 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL204822 | — | Ki | = | 402.0 | nM | 6.40 |
| CHEMBL371861 | — | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL434952 | — | Ki | = | 721.0 | nM | 6.14 |
| CHEMBL378820 | — | Ki | = | 732.0 | nM | 6.13 |
| CHEMBL380433 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL379895 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL372834 | — | Ki | = | 1980.0 | nM | 5.70 |
| CHEMBL202964 | — | Ki | = | 2160.0 | nM | 5.67 |
| CHEMBL202540 | — | Ki | = | 2880.0 | nM | 5.54 |
| CHEMBL378808 | — | Ki | = | 3260.0 | nM | 5.49 |
| CHEMBL203620 | — | Ki | = | 3540.0 | nM | 5.45 |
| CHEMBL201669 | — | Ki | = | 4570.0 | nM | 5.34 |
| CHEMBL382361 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL202509 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL204915 | — | Ki | > | 10000.0 | nM | - |