Assay Detail
Functional
CHEMBL859112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human lung carcinoma Lu1 cell line
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Lu1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Miliusanes, a class of cytotoxic agents from Miliusa sinensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 5.47 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201380 | — | — | 1 | 6.37 |
| CHEMBL201704 | — | — | 1 | 6.20 |
| CHEMBL199332 | — | — | 1 | 6.12 |
| CHEMBL200132 | — | — | 1 | 6.10 |
| CHEMBL202978 | — | — | 1 | 6.08 |
| CHEMBL199601 | — | — | 1 | 6.00 |
| CHEMBL199604 | — | — | 1 | 5.98 |
| CHEMBL201590 | — | — | 1 | 5.94 |
| CHEMBL380823 | — | — | 1 | 5.91 |
| CHEMBL383649 | — | — | 1 | 5.84 |
| CHEMBL201238 | — | — | 1 | 5.84 |
| CHEMBL382849 | — | — | 1 | 5.79 |
| CHEMBL380657 | — | — | 1 | 5.77 |
| CHEMBL199953 | — | — | 1 | 5.76 |
| CHEMBL2448545 | (+)-MILIUSANE XVIII | — | 1 | 5.74 |
| CHEMBL203140 | — | — | 1 | 5.74 |
| CHEMBL440759 | — | — | 1 | 5.70 |
| CHEMBL382137 | — | — | 1 | 5.69 |
| CHEMBL413570 | — | — | 1 | 5.67 |
| CHEMBL370376 | — | — | 1 | 5.62 |
| CHEMBL201545 | — | — | 1 | 5.60 |
| CHEMBL383608 | — | — | 1 | 5.57 |
| CHEMBL201734 | — | — | 1 | 5.56 |
| CHEMBL381302 | — | — | 1 | 5.54 |
| CHEMBL202664 | — | — | 1 | 5.52 |
| CHEMBL198407 | — | — | 1 | 5.51 |
| CHEMBL201356 | — | — | 1 | 5.51 |
| CHEMBL201345 | — | — | 1 | 5.50 |
| CHEMBL202975 | — | — | 1 | 5.50 |
| CHEMBL202976 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201380 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL201704 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL199332 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL200132 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL202978 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL199601 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL199604 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL201590 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL380823 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL383649 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL201238 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL382849 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL380657 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL199953 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL203140 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL2448545 | (+)-MILIUSANE XVIII | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL440759 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL382137 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL413570 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL370376 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL201545 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL383608 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL201734 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL381302 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL202664 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL198407 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL201356 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL201345 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL202975 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL202976 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL437138 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL369978 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL199942 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL202379 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL381989 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL199889 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL381044 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL199556 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL377948 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL381859 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL201487 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL201319 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL202778 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL201134 | — | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL382802 | — | IC50 | = | 5760.0 | nM | 5.24 |
| CHEMBL425038 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL201123 | — | IC50 | = | 6160.0 | nM | 5.21 |
| CHEMBL201078 | — | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL201741 | — | IC50 | = | 6610.0 | nM | 5.18 |
| CHEMBL380751 | — | IC50 | = | 7130.0 | nM | 5.15 |