Assay Detail
Functional
CHEMBL859149
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Cytotoxicity against human oral epidermoid carcinoma KB cell line
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Miliusanes, a class of cytotoxic agents from Miliusa sinensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 5.58 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201380 | — | — | 1 | 6.44 |
| CHEMBL199332 | — | — | 1 | 6.35 |
| CHEMBL380823 | — | — | 1 | 6.16 |
| CHEMBL199601 | — | — | 1 | 6.10 |
| CHEMBL201238 | — | — | 1 | 6.08 |
| CHEMBL200132 | — | — | 1 | 6.06 |
| CHEMBL201590 | — | — | 1 | 6.06 |
| CHEMBL199604 | — | — | 1 | 6.04 |
| CHEMBL380657 | — | — | 1 | 6.02 |
| CHEMBL383649 | — | — | 1 | 6.00 |
| CHEMBL201704 | — | — | 1 | 5.96 |
| CHEMBL440759 | — | — | 1 | 5.93 |
| CHEMBL381859 | — | — | 1 | 5.93 |
| CHEMBL382849 | — | — | 1 | 5.93 |
| CHEMBL381302 | — | — | 1 | 5.85 |
| CHEMBL201487 | — | — | 1 | 5.85 |
| CHEMBL199953 | — | — | 1 | 5.83 |
| CHEMBL202978 | — | — | 1 | 5.82 |
| CHEMBL380751 | — | — | 1 | 5.78 |
| CHEMBL381044 | — | — | 1 | 5.74 |
| CHEMBL201345 | — | — | 1 | 5.74 |
| CHEMBL201545 | — | — | 1 | 5.70 |
| CHEMBL198407 | — | — | 1 | 5.70 |
| CHEMBL201078 | — | — | 1 | 5.67 |
| CHEMBL201356 | — | — | 1 | 5.67 |
| CHEMBL413570 | — | — | 1 | 5.66 |
| CHEMBL382137 | — | — | 1 | 5.64 |
| CHEMBL201734 | — | — | 1 | 5.63 |
| CHEMBL383608 | — | — | 1 | 5.61 |
| CHEMBL203140 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201380 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL199332 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL380823 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL199601 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL201238 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL200132 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL201590 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL199604 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL380657 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL383649 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL201704 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL440759 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL381859 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL382849 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL201487 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL381302 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL199953 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL202978 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL380751 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL381044 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL201345 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL201545 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL198407 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL201078 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL201356 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL413570 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL382137 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL201734 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL383608 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL203140 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL199942 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL202664 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL437138 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL199556 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL369978 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2448545 | (+)-MILIUSANE XVIII | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL199889 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL201134 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL202975 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL381989 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL201741 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL370376 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL202976 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL202379 | — | IC50 | = | 4590.0 | nM | 5.34 |
| CHEMBL202778 | — | IC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL437511 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL383534 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL201319 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL425038 | — | IC50 | = | 5450.0 | nM | 5.26 |
| CHEMBL377948 | — | IC50 | = | 5820.0 | nM | 5.24 |