Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL859169

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of FabZ
17
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 9 — Direct single protein target
Curated By Expert

Target

Fatty acid synthase (CHEMBL4512)
Type SINGLE PROTEIN
Organism Plasmodium falciparum

Publication

Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Tasdemir D, Lack G, Brun R, Rüedi P, Scapozza L, Perozzo R.
J Med Chem (2006) 49 : 3345 -3353
PubMed 16722653 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.43 6.40
Ki 2 5.25 5.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL36327 EPICATECHIN GALLATE 1 6.40
CHEMBL297453 EPIGALOCATECHIN GALLATE 3.0 1 6.40
CHEMBL129451 (-)-CATECHINGALLATE 2 6.40
CHEMBL264938 GALLOCATECHIN GALLATE 1 6.22
CHEMBL50 QUERCETIN 3.0 1 5.82
CHEMBL31574 FISETIN 2.0 1 5.70
CHEMBL164 MYRICETIN 1 5.70
CHEMBL151 LUTEOLIN 2.0 2 5.30
CHEMBL44 GENISTEIN 2.0 1 5.16
CHEMBL28626 MORIN 1 5.10
CHEMBL131921 BIOCHANIN 1 5.10
CHEMBL276915 7-HYDROXYFLAVONE 1 4.70
CHEMBL138649 6-HYDROXYFLAVONE 1 4.52
CHEMBL8145 DAIDZEIN 2.0 1 4.52
CHEMBL207954 1 4.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL297453 EPIGALOCATECHIN GALLATE IC50 = 400.0 nM 6.40
CHEMBL129451 (-)-CATECHINGALLATE IC50 = 400.0 nM 6.40
CHEMBL36327 EPICATECHIN GALLATE IC50 = 400.0 nM 6.40
CHEMBL264938 GALLOCATECHIN GALLATE IC50 = 600.0 nM 6.22
CHEMBL50 QUERCETIN IC50 = 1500.0 nM 5.82
CHEMBL31574 FISETIN IC50 = 2000.0 nM 5.70
CHEMBL164 MYRICETIN IC50 = 2000.0 nM 5.70
CHEMBL129451 (-)-CATECHINGALLATE Ki = 2800.0 nM 5.55
CHEMBL151 LUTEOLIN IC50 = 5000.0 nM 5.30
CHEMBL44 GENISTEIN IC50 = 7000.0 nM 5.16
CHEMBL28626 MORIN IC50 = 8000.0 nM 5.10
CHEMBL131921 BIOCHANIN IC50 = 8000.0 nM 5.10
CHEMBL151 LUTEOLIN Ki = 11500.0 nM 4.94
CHEMBL276915 7-HYDROXYFLAVONE IC50 = 20000.0 nM 4.70
CHEMBL138649 6-HYDROXYFLAVONE IC50 = 30000.0 nM 4.52
CHEMBL8145 DAIDZEIN IC50 = 30000.0 nM 4.52
CHEMBL207954 IC50 = 40000.0 nM 4.40