Assay Detail
Binding
CHEMBL859178
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Inhibition of FabG in presence of NADPH
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3-oxoacyl-acyl-carrier protein reductase (CHEMBL4513) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.83 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 6.10 |
| CHEMBL129451 | (-)-CATECHINGALLATE | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL151 | LUTEOLIN | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL129451 | (-)-CATECHINGALLATE | Ki | = | 2800.0 | nM | 5.55 |