Assay Detail
Functional
CHEMBL859211
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Antiviral activity against HCMV AD-169 replication
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.02 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206291 | — | — | 1 | 9.05 |
| CHEMBL203321 | BRINCIDOFOVIR | 4.0 | 1 | 9.05 |
| CHEMBL381753 | — | — | 1 | 8.52 |
| CHEMBL203496 | — | — | 1 | 8.52 |
| CHEMBL382196 | — | — | 1 | 8.52 |
| CHEMBL204711 | — | — | 1 | 8.52 |
| CHEMBL286534 | — | — | 1 | 6.09 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206291 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL203321 | BRINCIDOFOVIR | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL381753 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL203496 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL382196 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL204711 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL286534 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 1200.0 | nM | 5.92 |