Assay Detail
Binding
CHEMBL859247
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human PARP1 expressed in PC12 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.03 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338790 | — | — | 1 | 7.58 |
| CHEMBL204250 | — | — | 1 | 7.44 |
| CHEMBL201907 | — | — | 1 | 7.40 |
| CHEMBL201931 | — | — | 1 | 7.05 |
| CHEMBL380809 | — | — | 1 | 6.16 |
| CHEMBL373066 | — | — | 1 | 6.12 |
| CHEMBL380940 | — | — | 1 | 5.70 |
| CHEMBL381280 | — | — | 1 | 5.65 |
| CHEMBL201723 | — | — | 1 | 5.30 |
| CHEMBL381303 | — | — | 1 | 5.00 |
| CHEMBL202426 | — | — | 1 | 5.00 |
| CHEMBL370869 | — | — | 1 | 5.00 |
| CHEMBL202537 | — | — | 1 | 5.00 |
| CHEMBL201728 | — | — | 1 | - |
| CHEMBL381460 | — | — | 1 | - |
| CHEMBL383830 | — | — | 1 | - |
| CHEMBL421087 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338790 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL204250 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL201907 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL201931 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL380809 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL373066 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL380940 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL381280 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL201723 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL381303 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL202426 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL370869 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL202537 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL201728 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL381460 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL383830 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL421087 | — | IC50 | > | 10000.0 | nM | - |