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Assay Detail

CHEMBL859281

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of falcipain2
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Falcipain 2 (CHEMBL5800)
Type SINGLE PROTEIN
Organism Plasmodium falciparum

Publication

Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory.
Desai PV, Patny A, Gut J, Rosenthal PJ, Tekwani B, Srivastava A, Avery M.
J Med Chem (2006) 49 : 1576 -1584
PubMed 16509575 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.13 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL374508 E-64 1 7.82
CHEMBL381093 1 5.85
CHEMBL203801 1 5.80
CHEMBL203802 1 5.54
CHEMBL204344 1 5.47
CHEMBL203823 1 5.34
CHEMBL203649 1 5.27
CHEMBL203856 1 5.19
CHEMBL383231 1 4.98
CHEMBL204035 1 4.97
CHEMBL380140 1 4.88
CHEMBL440764 1 4.86
CHEMBL205056 1 4.84
CHEMBL204491 1 4.82
CHEMBL379228 1 4.72
CHEMBL382027 1 4.32
CHEMBL204452 1 4.30
CHEMBL204850 1 4.28
CHEMBL204973 1 4.26

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL374508 E-64 IC50 = 15.0 nM 7.82
CHEMBL381093 IC50 = 1400.0 nM 5.85
CHEMBL203801 IC50 = 1600.0 nM 5.80
CHEMBL203802 IC50 = 2900.0 nM 5.54
CHEMBL204344 IC50 = 3400.0 nM 5.47
CHEMBL203823 IC50 = 4600.0 nM 5.34
CHEMBL203649 IC50 = 5400.0 nM 5.27
CHEMBL203856 IC50 = 6500.0 nM 5.19
CHEMBL383231 IC50 = 10400.0 nM 4.98
CHEMBL204035 IC50 = 10800.0 nM 4.97
CHEMBL380140 IC50 = 13200.0 nM 4.88
CHEMBL440764 IC50 = 13800.0 nM 4.86
CHEMBL205056 IC50 = 14300.0 nM 4.84
CHEMBL204491 IC50 = 15300.0 nM 4.82
CHEMBL379228 IC50 = 19000.0 nM 4.72
CHEMBL382027 IC50 = 47800.0 nM 4.32
CHEMBL204452 IC50 = 50000.0 nM 4.30
CHEMBL204850 IC50 = 52300.0 nM 4.28
CHEMBL204973 IC50 = 54300.0 nM 4.26