Assay Detail
Binding
CHEMBL859289
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Inhibitory activity against Aurora A
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.33 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382667 | — | — | 1 | 9.82 |
| CHEMBL203945 | — | — | 1 | 9.10 |
| CHEMBL381724 | — | — | 1 | 8.52 |
| CHEMBL204318 | — | — | 1 | 7.77 |
| CHEMBL203007 | — | — | 1 | 7.16 |
| CHEMBL204217 | — | — | 1 | 7.07 |
| CHEMBL202721 | — | — | 1 | 6.96 |
| CHEMBL382590 | ANILINOQUINAZOLINE1 | — | 1 | 6.41 |
| CHEMBL206266 | — | — | 1 | 6.20 |
| CHEMBL203507 | — | — | 1 | 6.16 |
| CHEMBL206374 | — | — | 1 | 5.41 |
| CHEMBL205877 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382667 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL203945 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL381724 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL204318 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL203007 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL204217 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL202721 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL382590 | ANILINOQUINAZOLINE1 | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL206266 | — | IC50 | = | 629.0 | nM | 6.20 |
| CHEMBL203507 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL206374 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL205877 | — | IC50 | < | 0.1 | nM | - |