Assay Detail
Functional
CHEMBL859290
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Antiproliferative activity against MCF7 cell line
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.95 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382667 | — | — | 1 | 7.70 |
| CHEMBL203945 | — | — | 1 | 7.62 |
| CHEMBL205877 | — | — | 1 | 7.10 |
| CHEMBL202721 | — | — | 1 | 6.70 |
| CHEMBL381724 | — | — | 1 | 6.68 |
| CHEMBL382590 | ANILINOQUINAZOLINE1 | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382667 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL203945 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL205877 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL202721 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL381724 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL382590 | ANILINOQUINAZOLINE1 | IC50 | = | 1250.0 | nM | 5.90 |