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Assay Detail

CHEMBL859295

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against KB cell line
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB
Confidence 1 — Organism
Curated By Expert

Target

KB (CHEMBL398)
Type CELL-LINE
Organism Homo sapiens

Publication

Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.
Coro J, Atherton R, Little S, Wharton H, Yardley V, Alvarez A, Súarez M, Pérez R, Rodríguez H.
Bioorg Med Chem Lett (2006) 16 : 1312 -1315
PubMed 16343898 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.23 8.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL61 PODOFILOX 4.0 1 8.44
CHEMBL382040 1 5.93
CHEMBL203130 1 5.66
CHEMBL204546 1 5.29
CHEMBL380734 1 5.24
CHEMBL264313 1 5.09
CHEMBL203648 1 5.08
CHEMBL204953 1 4.93
CHEMBL383681 1 4.91
CHEMBL203662 1 4.79
CHEMBL203490 1 4.28
CHEMBL204817 1 4.28
CHEMBL204745 1 4.12
CHEMBL425763 1 -
CHEMBL203702 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL61 PODOFILOX IC50 = 3.6 nM 8.44
CHEMBL382040 IC50 = 1170.0 nM 5.93
CHEMBL203130 IC50 = 2210.0 nM 5.66
CHEMBL204546 IC50 = 5090.0 nM 5.29
CHEMBL380734 IC50 = 5730.0 nM 5.24
CHEMBL264313 IC50 = 8160.0 nM 5.09
CHEMBL203648 IC50 = 8330.0 nM 5.08
CHEMBL204953 IC50 = 11670.0 nM 4.93
CHEMBL383681 IC50 = 12330.0 nM 4.91
CHEMBL203662 IC50 = 16090.0 nM 4.79
CHEMBL203490 IC50 = 52000.0 nM 4.28
CHEMBL204817 IC50 = 52540.0 nM 4.28
CHEMBL204745 IC50 = 76290.0 nM 4.12
CHEMBL425763 IC50 > 51720.0 nM -
CHEMBL203702 IC50 < 520.0 nM -