Assay Detail
Binding
CHEMBL859320
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Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.29 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264491 | — | — | 1 | 8.01 |
| CHEMBL347796 | — | — | 1 | 7.85 |
| CHEMBL275035 | — | — | 1 | 7.40 |
| CHEMBL153067 | — | — | 1 | 7.09 |
| CHEMBL356449 | — | — | 1 | 7.08 |
| CHEMBL275507 | — | — | 1 | 6.80 |
| CHEMBL90 | HISTAMINE | 4.0 | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264491 | — | EC50 | = | 9.772 | nM | 8.01 |
| CHEMBL347796 | — | EC50 | = | 14.13 | nM | 7.85 |
| CHEMBL275035 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL153067 | — | EC50 | = | 81.28 | nM | 7.09 |
| CHEMBL356449 | — | EC50 | = | 83.18 | nM | 7.08 |
| CHEMBL275507 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL90 | HISTAMINE | EC50 | = | 162.18 | nM | 6.79 |