Assay Detail
Functional
CHEMBL859403
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pA2 value was calculated from dose-response plots generated by using different concentrations ranging between 1 and 10 uM antagonist.
10
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Topographical amino acid substitution in position 10 of glucagon leads to antagonists/partial agonists with greater binding differences.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 6.29 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2115191 | — | — | 1 | 6.85 |
| CHEMBL413666 | — | — | 1 | 6.60 |
| CHEMBL2369127 | — | — | 1 | 6.50 |
| CHEMBL328942 | — | — | 3 | 6.20 |
| CHEMBL3037804 | — | — | 1 | 6.20 |
| CHEMBL2114177 | — | — | 1 | 6.20 |
| CHEMBL2114176 | — | — | 1 | 6.20 |
| CHEMBL2115192 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2115191 | — | Kd | = | 141.25 | nM | 6.85 |
| CHEMBL413666 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL2369127 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL3037804 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL328942 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL2114177 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL2114176 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL328942 | — | Kd | = | 707.95 | nM | 6.15 |
| CHEMBL328942 | — | Kd | = | 794.33 | nM | 6.10 |
| CHEMBL2115192 | — | Kd | = | 1412.54 | nM | 5.85 |