Assay Detail
Binding
CHEMBL859405
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Partial affinity towards Alpha-1 adrenergic receptor was assessed on rat aortic strips
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The furoxan system as a useful tool for balancing "hybrids" with mixed alpha 1-antagonist and NO-like vasodilator activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 8.75 | 9.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.81 |
| CHEMBL147984 | — | — | 1 | 9.17 |
| CHEMBL145838 | — | — | 1 | 8.96 |
| CHEMBL358498 | — | — | 1 | 8.55 |
| CHEMBL147624 | — | — | 1 | 8.49 |
| CHEMBL146481 | — | — | 1 | 8.25 |
| CHEMBL343188 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Kd | = | 0.1549 | nM | 9.81 |
| CHEMBL147984 | — | Kd | = | 0.6761 | nM | 9.17 |
| CHEMBL145838 | — | Kd | = | 1.096 | nM | 8.96 |
| CHEMBL358498 | — | Kd | = | 2.818 | nM | 8.55 |
| CHEMBL147624 | — | Kd | = | 3.236 | nM | 8.49 |
| CHEMBL146481 | — | Kd | = | 5.623 | nM | 8.25 |
| CHEMBL343188 | — | Kd | = | 9.12 | nM | 8.04 |