Assay Detail
Binding
CHEMBL859693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human SIRT1 by radiochemical Nicotinamide release assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
NAD-dependent protein deacetylase sirtuin-1 (CHEMBL4506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.79 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446446 | — | — | 1 | 6.19 |
| CHEMBL420311 | — | — | 1 | 5.89 |
| CHEMBL115600 | — | — | 1 | 5.60 |
| CHEMBL112265 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446446 | — | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL420311 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL115600 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL112265 | — | IC50 | = | 3300.0 | nM | 5.48 |