Assay Detail
Functional
CHEMBL859808
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Growth inhibition in human breast cancer MDA-MB-468 cell line using SRB
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.45 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | 2.0 | 1 | 7.24 |
| CHEMBL200001 | — | — | 1 | 7.05 |
| CHEMBL377482 | — | — | 1 | 6.82 |
| CHEMBL372962 | — | — | 1 | 6.77 |
| CHEMBL383189 | — | — | 1 | 6.57 |
| CHEMBL199283 | — | — | 1 | 6.46 |
| CHEMBL201683 | — | — | 1 | 6.36 |
| CHEMBL365159 | — | — | 1 | 6.25 |
| CHEMBL199505 | — | — | 1 | 4.56 |
| CHEMBL372791 | — | — | 1 | - |
| CHEMBL202777 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL200001 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL377482 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL372962 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL383189 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL199283 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL201683 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL365159 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL199505 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL372791 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL202777 | — | IC50 | > | 50000.0 | nM | - |