Assay Detail
Binding
CHEMBL859924
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human aPC
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.92 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436766 | — | — | 1 | 5.24 |
| CHEMBL379036 | — | — | 1 | 4.89 |
| CHEMBL381949 | — | — | 1 | 4.82 |
| CHEMBL206335 | RAZAXABAN | 2.0 | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436766 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL379036 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL381949 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL206335 | RAZAXABAN | Ki | = | 19700.0 | nM | 4.71 |