Assay Detail
Functional
CHEMBL859988
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Intrinsic activity against dopamine D2(short) receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.81 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379602 | — | — | 1 | 9.66 |
| CHEMBL378455 | — | — | 1 | 8.77 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379602 | — | EC50 | = | 0.22 | nM | 9.66 |
| CHEMBL378455 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL240773 | QUINPIROLE | EC50 | = | 10.0 | nM | 8.00 |