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Assay Detail

CHEMBL860036

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CHA from adenosine A1 receptor in bovine cerebral cortical membranes
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Adenosine receptor A1 (CHEMBL4975)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives.
Catarzi D, Colotta V, Varano F, Lenzi O, Filacchioni G, Trincavelli L, Martini C, Montopoli C, Moro S.
J Med Chem (2005) 48 : 7932 -7945
PubMed 16335918 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 6.24 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL183 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] 1 9.30
CHEMBL8966 1 8.30
CHEMBL200835 1 7.30
CHEMBL200479 1 6.82
CHEMBL197333 1 6.57
CHEMBL371697 1 6.29
CHEMBL197325 1 6.28
CHEMBL334286 1 6.24
CHEMBL97286 1 6.00
CHEMBL98678 1 5.97
CHEMBL200687 1 5.97
CHEMBL330399 1 5.95
CHEMBL197376 1 5.84
CHEMBL327853 1 5.71
CHEMBL198574 1 5.62
CHEMBL328437 1 5.53
CHEMBL325715 1 5.49
CHEMBL316824 1 5.44
CHEMBL1355736 THEOPHYLLINE 4.0 1 5.42
CHEMBL8907 1 4.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL183 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] Ki = 0.5 nM 9.30
CHEMBL8966 Ki = 5.0 nM 8.30
CHEMBL200835 Ki = 50.0 nM 7.30
CHEMBL200479 Ki = 150.0 nM 6.82
CHEMBL197333 Ki = 268.0 nM 6.57
CHEMBL371697 Ki = 508.0 nM 6.29
CHEMBL197325 Ki = 525.0 nM 6.28
CHEMBL334286 Ki = 578.0 nM 6.24
CHEMBL97286 Ki = 1000.0 nM 6.00
CHEMBL98678 Ki = 1060.0 nM 5.97
CHEMBL200687 Ki = 1080.0 nM 5.97
CHEMBL330399 Ki = 1130.0 nM 5.95
CHEMBL197376 Ki = 1440.0 nM 5.84
CHEMBL327853 Ki = 1950.0 nM 5.71
CHEMBL198574 Ki = 2400.0 nM 5.62
CHEMBL328437 Ki = 2940.0 nM 5.53
CHEMBL325715 Ki = 3220.0 nM 5.49
CHEMBL316824 Ki = 3660.0 nM 5.44
CHEMBL1355736 THEOPHYLLINE Ki = 3800.0 nM 5.42
CHEMBL8907 Ki = 14170.0 nM 4.85