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Assay Detail

CHEMBL860055

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Binding
Inhibition of Cdk5/p25
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors.
Vandromme L, Piguel S, Lozach O, Meijer L, Legraverend M, Grierson DS.
Bioorg Med Chem Lett (2006) 16 : 3144 -3146
PubMed 16616489 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.60 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL377061 1 5.89
CHEMBL379029 1 5.85
CHEMBL437325 1 5.75
CHEMBL209404 1 5.66
CHEMBL208017 1 5.55
CHEMBL210839 1 5.52
CHEMBL207426 1 5.47
CHEMBL379811 1 5.40
CHEMBL379618 1 5.31
CHEMBL24484 1 -
CHEMBL422759 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL377061 IC50 = 1300.0 nM 5.89
CHEMBL379029 IC50 = 1400.0 nM 5.85
CHEMBL437325 IC50 = 1800.0 nM 5.75
CHEMBL209404 IC50 = 2200.0 nM 5.66
CHEMBL208017 IC50 = 2800.0 nM 5.55
CHEMBL210839 IC50 = 3000.0 nM 5.52
CHEMBL207426 IC50 = 3400.0 nM 5.47
CHEMBL379811 IC50 = 4000.0 nM 5.40
CHEMBL379618 IC50 = 4900.0 nM 5.31
CHEMBL24484 IC50 - -
CHEMBL422759 IC50 - -