Assay Detail
Binding
CHEMBL860111
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of canine retinal cone PDE6
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (CHEMBL3977) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A novel series of potent and selective PDE5 inhibitors with potential for high and dose-independent oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.43 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377168 | — | — | 1 | 9.05 |
| CHEMBL209460 | — | — | 1 | 8.85 |
| CHEMBL210603 | — | — | 1 | 6.74 |
| CHEMBL209157 | — | — | 1 | 6.41 |
| CHEMBL210930 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377168 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL209460 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL210603 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL209157 | — | IC50 | = | 386.0 | nM | 6.41 |
| CHEMBL210930 | — | IC50 | = | 840.0 | nM | 6.08 |