Assay Detail
Functional
CHEMBL860135
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Inhibition of LPS-induced TNFalpha production in squirrel monkey whole blood
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Saimiri sciureus |
| Tissue | Blood |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.33 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199015 | — | — | 1 | 8.30 |
| CHEMBL372575 | — | — | 1 | 7.96 |
| CHEMBL371037 | — | — | 1 | 7.82 |
| CHEMBL198564 | — | — | 1 | 6.35 |
| CHEMBL32442 | CDP840 | — | 1 | 6.22 |
| CHEMBL198527 | — | — | 1 | - |
| CHEMBL370220 | — | — | 1 | - |
| CHEMBL198432 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199015 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL372575 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL371037 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL198564 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL32442 | CDP840 | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL198527 | — | IC50 | - | — | - | |
| CHEMBL370220 | — | IC50 | - | — | - | |
| CHEMBL198432 | — | IC50 | - | — | - |