Assay Detail
Binding
CHEMBL860146
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human MCHr1 from neuronal IMR32 cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.32 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427367 | — | — | 1 | 8.30 |
| CHEMBL196973 | — | — | 1 | 8.22 |
| CHEMBL199025 | — | — | 1 | 8.15 |
| CHEMBL371222 | — | — | 1 | 8.10 |
| CHEMBL197232 | — | — | 1 | 8.05 |
| CHEMBL198835 | — | — | 1 | 7.70 |
| CHEMBL383359 | — | — | 1 | 7.70 |
| CHEMBL197497 | — | — | 1 | 7.70 |
| CHEMBL265540 | — | — | 1 | 7.70 |
| CHEMBL369986 | — | — | 1 | 7.70 |
| CHEMBL372848 | — | — | 1 | 7.70 |
| CHEMBL199222 | — | — | 1 | 7.52 |
| CHEMBL381013 | — | — | 1 | 7.52 |
| CHEMBL380782 | — | — | 1 | 7.40 |
| CHEMBL198890 | — | — | 1 | 7.40 |
| CHEMBL370576 | — | — | 1 | 7.40 |
| CHEMBL370361 | — | — | 1 | 7.30 |
| CHEMBL198789 | — | — | 1 | 7.30 |
| CHEMBL197395 | — | — | 1 | 7.30 |
| CHEMBL198588 | — | — | 1 | 7.16 |
| CHEMBL197283 | — | — | 1 | 7.00 |
| CHEMBL196972 | — | — | 1 | 6.96 |
| CHEMBL197281 | — | — | 1 | 6.82 |
| CHEMBL370360 | — | — | 1 | 6.70 |
| CHEMBL197059 | — | — | 1 | 6.66 |
| CHEMBL197058 | — | — | 1 | 6.62 |
| CHEMBL370222 | — | — | 1 | 6.55 |
| CHEMBL198692 | — | — | 1 | 6.48 |
| CHEMBL197023 | — | — | 1 | 6.36 |
| CHEMBL197485 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427367 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL196973 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL199025 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL371222 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL197232 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL198835 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL383359 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL197497 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL265540 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL369986 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL372848 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL199222 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL381013 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL380782 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL370576 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL198890 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL370361 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL198789 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL197395 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL198588 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL197283 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL196972 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL197281 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL370360 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL197059 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL197058 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL370222 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL198692 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL197023 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL197485 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL383150 | — | IC50 | > | 2000.0 | nM | - |