Assay Detail
Functional
CHEMBL860147
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.03 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371222 | — | — | 1 | 7.22 |
| CHEMBL196973 | — | — | 1 | 7.16 |
| CHEMBL199222 | — | — | 1 | 6.72 |
| CHEMBL383359 | — | — | 1 | 6.58 |
| CHEMBL197497 | — | — | 1 | 6.54 |
| CHEMBL427367 | — | — | 1 | 6.46 |
| CHEMBL198789 | — | — | 1 | 6.42 |
| CHEMBL381013 | — | — | 1 | 6.28 |
| CHEMBL197232 | — | — | 1 | 6.26 |
| CHEMBL199025 | — | — | 1 | 6.25 |
| CHEMBL372848 | — | — | 1 | 6.19 |
| CHEMBL369986 | — | — | 1 | 6.03 |
| CHEMBL196972 | — | — | 1 | 5.97 |
| CHEMBL265540 | — | — | 1 | 5.94 |
| CHEMBL197283 | — | — | 1 | 5.86 |
| CHEMBL380782 | — | — | 1 | 5.74 |
| CHEMBL198588 | — | — | 1 | 5.72 |
| CHEMBL198835 | — | — | 1 | 5.59 |
| CHEMBL197059 | — | — | 1 | 5.47 |
| CHEMBL197281 | — | — | 1 | 5.35 |
| CHEMBL197395 | — | — | 1 | 5.31 |
| CHEMBL370576 | — | — | 1 | 5.28 |
| CHEMBL197058 | — | — | 1 | 5.28 |
| CHEMBL370360 | — | — | 1 | 5.21 |
| CHEMBL198692 | — | — | 1 | - |
| CHEMBL383150 | — | — | 1 | - |
| CHEMBL197023 | — | — | 1 | - |
| CHEMBL370222 | — | — | 1 | - |
| CHEMBL370361 | — | — | 1 | - |
| CHEMBL198890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371222 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL196973 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL199222 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL383359 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL197497 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL427367 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL198789 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL381013 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL197232 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL199025 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL372848 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL369986 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL196972 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL265540 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL197283 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL380782 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL198588 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL198835 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL197059 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL197281 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL197395 | — | IC50 | = | 4910.0 | nM | 5.31 |
| CHEMBL370576 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL197058 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL370360 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL198692 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL383150 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL197023 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL370222 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL370361 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL198890 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL197485 | — | IC50 | > | 10000.0 | nM | - |