Assay Detail
Binding
CHEMBL860163
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Binding affinity to human adenosine A3 receptor in CHO cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.47 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573937 | — | — | 1 | 8.43 |
| CHEMBL2112177 | — | — | 1 | 7.88 |
| CHEMBL2112178 | — | — | 1 | 7.84 |
| CHEMBL284969 | — | — | 1 | 7.42 |
| CHEMBL176551 | — | — | 1 | 6.64 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573937 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL2112177 | — | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL2112178 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL284969 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL176551 | — | Ki | = | 229.0 | nM | 6.64 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 240.0 | nM | 6.62 |