Assay Detail
Binding
CHEMBL860171
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Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.28 | 7.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540818 | — | — | 1 | 7.76 |
| CHEMBL540563 | — | — | 1 | 7.75 |
| CHEMBL545278 | — | — | 1 | 7.75 |
| CHEMBL558980 | — | — | 1 | 7.58 |
| CHEMBL536483 | — | — | 1 | 7.58 |
| CHEMBL554450 | — | — | 1 | 7.54 |
| CHEMBL539545 | — | — | 1 | 7.53 |
| CHEMBL534695 | — | — | 1 | 7.50 |
| CHEMBL538566 | — | — | 1 | 7.50 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.49 |
| CHEMBL545508 | — | — | 1 | 7.49 |
| CHEMBL540573 | — | — | 1 | 7.44 |
| CHEMBL559178 | — | — | 1 | 7.41 |
| CHEMBL535363 | — | — | 1 | 7.31 |
| CHEMBL537842 | — | — | 1 | 7.31 |
| CHEMBL559377 | — | — | 1 | 7.27 |
| CHEMBL554663 | — | — | 1 | 7.23 |
| CHEMBL552542 | — | — | 1 | 7.22 |
| CHEMBL539333 | — | — | 1 | 7.19 |
| CHEMBL544343 | — | — | 1 | 7.17 |
| CHEMBL542701 | — | — | 1 | 7.06 |
| CHEMBL540361 | — | — | 1 | 7.03 |
| CHEMBL538772 | — | — | 1 | 6.98 |
| CHEMBL537399 | — | — | 1 | 6.94 |
| CHEMBL535366 | — | — | 1 | 6.82 |
| CHEMBL553091 | — | — | 1 | 6.76 |
| CHEMBL190883 | — | — | 1 | 6.67 |
| CHEMBL537177 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540818 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL540563 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL545278 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL558980 | — | Ki | = | 26.2 | nM | 7.58 |
| CHEMBL536483 | — | Ki | = | 26.3 | nM | 7.58 |
| CHEMBL554450 | — | Ki | = | 28.6 | nM | 7.54 |
| CHEMBL539545 | — | Ki | = | 29.5 | nM | 7.53 |
| CHEMBL534695 | — | Ki | = | 31.4 | nM | 7.50 |
| CHEMBL538566 | — | Ki | = | 31.4 | nM | 7.50 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 32.3 | nM | 7.49 |
| CHEMBL545508 | — | Ki | = | 32.7 | nM | 7.49 |
| CHEMBL540573 | — | Ki | = | 36.3 | nM | 7.44 |
| CHEMBL559178 | — | Ki | = | 38.9 | nM | 7.41 |
| CHEMBL535363 | — | Ki | = | 49.2 | nM | 7.31 |
| CHEMBL537842 | — | Ki | = | 48.7 | nM | 7.31 |
| CHEMBL559377 | — | Ki | = | 53.8 | nM | 7.27 |
| CHEMBL554663 | — | Ki | = | 59.3 | nM | 7.23 |
| CHEMBL552542 | — | Ki | = | 60.2 | nM | 7.22 |
| CHEMBL539333 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL544343 | — | Ki | = | 67.4 | nM | 7.17 |
| CHEMBL542701 | — | Ki | = | 86.2 | nM | 7.06 |
| CHEMBL540361 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL538772 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL537399 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL535366 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL553091 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL190883 | — | Ki | = | 212.0 | nM | 6.67 |
| CHEMBL537177 | — | Ki | = | 238.0 | nM | 6.62 |