Assay Detail
Functional
CHEMBL860185
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Inhibition of cJun phosphorylation in HepG2 cell line
23
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.80 | 6.55 |
| Ki | 6 | 7.47 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378627 | — | — | 2 | 8.40 |
| CHEMBL210618 | — | — | 2 | 8.40 |
| CHEMBL210963 | — | — | 2 | 8.05 |
| CHEMBL210928 | — | — | 2 | 7.89 |
| CHEMBL209769 | — | — | 1 | 6.55 |
| CHEMBL208637 | — | — | 2 | 6.36 |
| CHEMBL382639 | — | — | 1 | 6.05 |
| CHEMBL209505 | — | — | 1 | 6.04 |
| CHEMBL426134 | — | — | 1 | 5.85 |
| CHEMBL211009 | — | — | 1 | 5.85 |
| CHEMBL210655 | — | — | 1 | 5.85 |
| CHEMBL210462 | — | — | 1 | 5.80 |
| CHEMBL210032 | — | — | 1 | 5.72 |
| CHEMBL209291 | — | — | 1 | 5.60 |
| CHEMBL209192 | — | — | 1 | 5.47 |
| CHEMBL377578 | — | — | 1 | 5.41 |
| CHEMBL383308 | — | — | 1 | 5.26 |
| CHEMBL209669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378627 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL210618 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL210963 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL210928 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL209769 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL208637 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL378627 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL382639 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL209505 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL210618 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL210963 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL210655 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL426134 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL211009 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL210462 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL210928 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL210032 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL209291 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL209192 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL377578 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL383308 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL208637 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL209669 | — | EC50 | > | 10000.0 | nM | - |