Assay Detail
Binding
CHEMBL860208
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Inhibition of ERK2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.33 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378627 | — | — | 1 | 5.41 |
| CHEMBL210618 | — | — | 1 | 5.33 |
| CHEMBL210963 | — | — | 1 | 5.24 |
| CHEMBL208637 | — | — | 1 | - |
| CHEMBL210928 | — | — | 1 | - |
| CHEMBL210032 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378627 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL210618 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL210963 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL208637 | — | Ki | > | 8800.0 | nM | - |
| CHEMBL210928 | — | Ki | > | 8800.0 | nM | - |
| CHEMBL210032 | — | Ki | > | 8800.0 | nM | - |