Assay Detail
Binding
CHEMBL860282
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cells
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 7.47 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199062 | — | — | 1 | 8.52 |
| CHEMBL129198 | JNJ-7777120 | — | 1 | 8.40 |
| CHEMBL129436 | — | — | 1 | 8.30 |
| CHEMBL120591 | — | — | 1 | 8.15 |
| CHEMBL129488 | — | — | 1 | 8.15 |
| CHEMBL128613 | — | — | 1 | 8.10 |
| CHEMBL129540 | — | — | 1 | 8.10 |
| CHEMBL338937 | — | — | 1 | 7.96 |
| CHEMBL129444 | — | — | 1 | 7.85 |
| CHEMBL436381 | — | — | 1 | 7.82 |
| CHEMBL340740 | — | — | 1 | 7.82 |
| CHEMBL129199 | — | — | 1 | 7.77 |
| CHEMBL338051 | — | — | 1 | 7.72 |
| CHEMBL333220 | — | — | 1 | 7.72 |
| CHEMBL199231 | — | — | 1 | 7.68 |
| CHEMBL128958 | — | — | 1 | 7.64 |
| CHEMBL120854 | — | — | 1 | 7.64 |
| CHEMBL364400 | — | — | 1 | 7.60 |
| CHEMBL185951 | — | — | 1 | 7.58 |
| CHEMBL268525 | — | — | 1 | 7.57 |
| CHEMBL383384 | — | — | 1 | 7.52 |
| CHEMBL129026 | — | — | 1 | 7.51 |
| CHEMBL128505 | — | — | 1 | 7.50 |
| CHEMBL187285 | — | — | 1 | 7.48 |
| CHEMBL382276 | — | — | 1 | 7.46 |
| CHEMBL129660 | — | — | 1 | 7.42 |
| CHEMBL370135 | — | — | 1 | 7.40 |
| CHEMBL128088 | — | — | 1 | 7.34 |
| CHEMBL338972 | — | — | 1 | 7.31 |
| CHEMBL128252 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199062 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL129198 | JNJ-7777120 | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL129436 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL120591 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL129488 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL128613 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL129540 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL338937 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL129444 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL436381 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL340740 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL129199 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL338051 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL333220 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL199231 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL128958 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL120854 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL364400 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL185951 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL268525 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL383384 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL129026 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL128505 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL187285 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL382276 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL129660 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL370135 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL128088 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL338972 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL128252 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL200546 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL362495 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL120221 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL338001 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL2113162 | — | Ki | = | 244.0 | nM | 6.61 |
| CHEMBL197477 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL331773 | — | Ki | = | 427.0 | nM | 6.37 |
| CHEMBL121679 | — | Ki | = | 528.0 | nM | 6.28 |
| CHEMBL128637 | — | Ki | = | 3000.0 | nM | 5.52 |