Assay Detail
Binding
CHEMBL860314
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human platelet heparanase by Microcon ultrafiltration assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, biological activity, and preliminary pharmacokinetic evaluation of analogues of a phosphosulfomannan angiogenesis inhibitor (PI-88).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.74 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198643 | — | — | 1 | 5.79 |
| CHEMBL382044 | — | — | 1 | 5.74 |
| CHEMBL262707 | — | — | 1 | 5.73 |
| CHEMBL265885 | — | — | 1 | 5.70 |
| CHEMBL373279 | — | — | 1 | - |
| CHEMBL264593 | — | — | 1 | - |
| CHEMBL438743 | — | — | 1 | - |
| CHEMBL412087 | — | — | 1 | - |
| CHEMBL405383 | — | — | 1 | - |
| CHEMBL264125 | — | — | 1 | - |
| CHEMBL413401 | — | — | 1 | - |
| CHEMBL425275 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198643 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL382044 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL262707 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL265885 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL373279 | — | IC50 | - | — | - | |
| CHEMBL264593 | — | IC50 | - | — | - | |
| CHEMBL438743 | — | IC50 | - | — | - | |
| CHEMBL412087 | — | IC50 | - | — | - | |
| CHEMBL405383 | — | IC50 | - | — | - | |
| CHEMBL264125 | — | IC50 | - | — | - | |
| CHEMBL413401 | — | IC50 | - | — | - | |
| CHEMBL425275 | — | IC50 | - | — | - |