Assay Detail
Binding
CHEMBL860331
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Inhibitory activity against Src
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.84 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199210 | — | — | 1 | 5.52 |
| CHEMBL371658 | — | — | 1 | 5.40 |
| CHEMBL197538 | — | — | 1 | 4.40 |
| CHEMBL371095 | — | — | 1 | 4.05 |
| CHEMBL200381 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199210 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL371658 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL197538 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL371095 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL200381 | — | IC50 | > | 400000.0 | nM | - |