Assay Detail
Binding
CHEMBL860418
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to trypsin
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 5.19 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200153 | — | — | 1 | 7.00 |
| CHEMBL200573 | — | — | 1 | 6.85 |
| CHEMBL371769 | — | — | 1 | 6.62 |
| CHEMBL381205 | — | — | 1 | 5.64 |
| CHEMBL96502 | — | — | 1 | 5.22 |
| CHEMBL371650 | — | — | 1 | 5.19 |
| CHEMBL200134 | — | — | 1 | 5.14 |
| CHEMBL370557 | — | — | 1 | 5.02 |
| CHEMBL200857 | — | — | 1 | 4.77 |
| CHEMBL200593 | — | — | 1 | 4.68 |
| CHEMBL199696 | — | — | 1 | 4.50 |
| CHEMBL265363 | — | — | 1 | 4.44 |
| CHEMBL373260 | — | — | 1 | 4.37 |
| CHEMBL200674 | — | — | 1 | 4.23 |
| CHEMBL199675 | — | — | 1 | 4.23 |
| CHEMBL199609 | — | — | 1 | - |
| CHEMBL200110 | — | — | 1 | - |
| CHEMBL200920 | — | — | 1 | - |
| CHEMBL200520 | — | — | 1 | - |
| CHEMBL200504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200153 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL200573 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL371769 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL381205 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL96502 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL371650 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL200134 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL370557 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL200857 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL200593 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL199696 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL265363 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL373260 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL200674 | — | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL199675 | — | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL199609 | — | Ki | = | 178000.0 | nM | - |
| CHEMBL200110 | — | Ki | = | 314000.0 | nM | - |
| CHEMBL200920 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL200520 | — | Ki | = | 124000.0 | nM | - |
| CHEMBL200504 | — | Ki | > | 1000000.0 | nM | - |