Assay Detail
Functional
CHEMBL860501
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Antiviral activity against wild type HBV in human hepatoma 2.2.15 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Effect of various pyrimidines possessing the 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl] moiety, able to mimic natural 2'-deoxyribose, on wild-type and mutant hepatitis B virus replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 4.85 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 5.68 |
| CHEMBL377998 | — | — | 1 | 4.70 |
| CHEMBL376946 | — | — | 1 | 4.52 |
| CHEMBL210736 | — | — | 1 | 4.49 |
| CHEMBL333559 | — | — | 1 | - |
| CHEMBL210916 | — | — | 1 | - |
| CHEMBL209621 | — | — | 1 | - |
| CHEMBL208654 | IODMETACYCLUR | — | 1 | - |
| CHEMBL210828 | — | — | 1 | - |
| CHEMBL210664 | — | — | 1 | - |
| CHEMBL207010 | — | — | 1 | - |
| CHEMBL35047 | — | — | 1 | - |
| CHEMBL36394 | — | — | 1 | - |
| CHEMBL379526 | — | — | 1 | - |
| CHEMBL37840 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141 | LAMIVUDINE | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL377998 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL376946 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL210736 | — | EC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL333559 | — | EC50 | > | 42700.0 | nM | - |
| CHEMBL210916 | — | EC50 | > | 43200.0 | nM | - |
| CHEMBL209621 | — | EC50 | > | 46000.0 | nM | - |
| CHEMBL208654 | IODMETACYCLUR | EC50 | > | 28000.0 | nM | - |
| CHEMBL210828 | — | EC50 | > | 32300.0 | nM | - |
| CHEMBL210664 | — | EC50 | > | 38400.0 | nM | - |
| CHEMBL207010 | — | EC50 | > | 41000.0 | nM | - |
| CHEMBL35047 | — | EC50 | > | 43400.0 | nM | - |
| CHEMBL36394 | — | EC50 | > | 43200.0 | nM | - |
| CHEMBL379526 | — | EC50 | > | 38300.0 | nM | - |
| CHEMBL37840 | — | EC50 | > | 33800.0 | nM | - |