Assay Detail
Binding
CHEMBL860509
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human D4 receptor expressed in CHO cells
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Fancy bioisosteres: novel paracyclophane derivatives as super-affinity dopamine D3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.52 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210567 | — | — | 2 | 8.27 |
| CHEMBL426863 | — | — | 1 | 7.75 |
| CHEMBL209876 | — | — | 1 | 7.48 |
| CHEMBL25236 | BP-897 | — | 1 | 7.36 |
| CHEMBL210461 | — | — | 1 | 6.92 |
| CHEMBL208847 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210567 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL210567 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL426863 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL209876 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL25236 | BP-897 | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL210461 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL208847 | — | Ki | = | 140.0 | nM | 6.85 |