Assay Detail
Binding
CHEMBL860565
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Displacement of [3H]MPEP from mGluR5d in rat brain membrane
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Metabotropic glutamate receptor 5 (CHEMBL2564) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Phenyl ureas of creatinine as mGluR5 antagonists. A structure-activity relationship study of fenobam analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.03 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL202794 | — | — | 1 | 6.75 |
| CHEMBL202845 | — | — | 1 | 6.50 |
| CHEMBL239800 | FENOBAM ANHYDROUS | 2.0 | 1 | 6.34 |
| CHEMBL202802 | — | — | 1 | 5.92 |
| CHEMBL378365 | — | — | 1 | 5.89 |
| CHEMBL203720 | — | — | 1 | 5.89 |
| CHEMBL201827 | — | — | 1 | 5.80 |
| CHEMBL380626 | — | — | 1 | 5.70 |
| CHEMBL204445 | — | — | 1 | 5.47 |
| CHEMBL204201 | — | — | 1 | - |
| CHEMBL204289 | — | — | 1 | - |
| CHEMBL201828 | — | — | 1 | - |
| CHEMBL203713 | — | — | 1 | - |
| CHEMBL380672 | — | — | 1 | - |
| CHEMBL203566 | — | — | 1 | - |
| CHEMBL377078 | — | — | 1 | - |
| CHEMBL204115 | — | — | 1 | - |
| CHEMBL204116 | — | — | 1 | - |
| CHEMBL204202 | — | — | 1 | - |
| CHEMBL382337 | — | — | 1 | - |
| CHEMBL382681 | — | — | 1 | - |
| CHEMBL275788 | — | — | 1 | - |
| CHEMBL247495 | — | — | 1 | - |
| CHEMBL424681 | — | — | 1 | - |
| CHEMBL204799 | — | — | 1 | - |
| CHEMBL204299 | — | — | 1 | - |
| CHEMBL204392 | — | — | 1 | - |
| CHEMBL381820 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL202794 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL202845 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL239800 | FENOBAM ANHYDROUS | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL202802 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL378365 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL203720 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL201827 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL380626 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL204445 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL204201 | — | IC50 | - | — | - | |
| CHEMBL204289 | — | IC50 | - | — | - | |
| CHEMBL201828 | — | IC50 | - | — | - | |
| CHEMBL203713 | — | IC50 | - | — | - | |
| CHEMBL380672 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL203566 | — | IC50 | - | — | - | |
| CHEMBL377078 | — | IC50 | - | — | - | |
| CHEMBL204115 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL204116 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL204202 | — | IC50 | - | — | - | |
| CHEMBL382337 | — | IC50 | - | — | - | |
| CHEMBL382681 | — | IC50 | - | — | - | |
| CHEMBL275788 | — | IC50 | - | — | - | |
| CHEMBL247495 | — | IC50 | - | — | - | |
| CHEMBL424681 | — | IC50 | - | — | - | |
| CHEMBL204799 | — | IC50 | - | — | - | |
| CHEMBL204299 | — | IC50 | - | — | - | |
| CHEMBL204392 | — | IC50 | - | — | - | |
| CHEMBL381820 | — | IC50 | - | — | - |