Assay Detail
Binding
CHEMBL860628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat liver mitochondria MAOA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.14 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206465 | — | — | 1 | 8.89 |
| CHEMBL379231 | — | — | 1 | 8.77 |
| CHEMBL381487 | — | — | 1 | 8.68 |
| CHEMBL203892 | — | — | 1 | 8.43 |
| CHEMBL382886 | — | — | 1 | 8.12 |
| CHEMBL379678 | — | — | 1 | 8.06 |
| CHEMBL203842 | — | — | 1 | 7.14 |
| CHEMBL204423 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206465 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL379231 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL381487 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL203892 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL382886 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL379678 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL203842 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL204423 | — | IC50 | = | 92.0 | nM | 7.04 |