Assay Detail
Binding
CHEMBL860642
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Average Binding Constant for MAP4K5; NA=Not Active at 10 uM
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Mitogen-activated protein kinase kinase kinase kinase 5 (CHEMBL4852) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A small molecule-kinase interaction map for clinical kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 20 | 6.47 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL607707 | PELITINIB | 2.0 | 1 | 8.43 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.58 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.11 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 6.29 |
| CHEMBL31965 | CANERTINIB | 3.0 | 1 | 5.89 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.77 |
| CHEMBL124660 | TANDUTINIB | 2.0 | 1 | 5.60 |
| CHEMBL91829 | RUBOXISTAURIN | 3.0 | 1 | 5.08 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | - |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | - |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | - |
| CHEMBL941 | IMATINIB | 4.0 | 1 | - |
| CHEMBL1725279 | SP-600125 | — | 1 | - |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | - |
| CHEMBL119385 | NEFLAMAPIMOD | 2.0 | 1 | - |
| CHEMBL10 | SB-203580 | — | 1 | - |
| CHEMBL278041 | SB-202190 | — | 1 | - |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | - |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL607707 | PELITINIB | Kd | = | 3.7 | nM | 8.43 |
| CHEMBL388978 | STAUROSPORINE | Kd | = | 26.0 | nM | 7.58 |
| CHEMBL535 | SUNITINIB | Kd | = | 77.0 | nM | 7.11 |
| CHEMBL24828 | VANDETANIB | Kd | = | 510.0 | nM | 6.29 |
| CHEMBL31965 | CANERTINIB | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL1336 | SORAFENIB | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL124660 | TANDUTINIB | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL91829 | RUBOXISTAURIN | Kd | = | 8400.0 | nM | 5.08 |
| CHEMBL554 | LAPATINIB | Kd | - | — | - | |
| CHEMBL101253 | VATALANIB | Kd | - | — | - | |
| CHEMBL553 | ERLOTINIB | Kd | - | — | - | |
| CHEMBL939 | GEFITINIB | Kd | - | — | - | |
| CHEMBL941 | IMATINIB | Kd | - | — | - | |
| CHEMBL1725279 | SP-600125 | Kd | - | — | - | |
| CHEMBL103667 | DORAMAPIMOD | Kd | - | — | - | |
| CHEMBL119385 | NEFLAMAPIMOD | Kd | - | — | - | |
| CHEMBL10 | SB-203580 | Kd | - | — | - | |
| CHEMBL278041 | SB-202190 | Kd | - | — | - | |
| CHEMBL428690 | ALVOCIDIB | Kd | - | — | - | |
| CHEMBL14762 | SELICICLIB | Kd | - | — | - |