Assay Detail
Functional
CHEMBL860691
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of febrifugine analogues as potential antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.13 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381176 | — | — | 1 | 9.41 |
| CHEMBL206613 | — | — | 1 | 9.39 |
| CHEMBL426494 | — | — | 1 | 8.89 |
| CHEMBL208004 | — | — | 1 | 8.89 |
| CHEMBL208041 | — | — | 1 | 8.89 |
| CHEMBL208509 | — | — | 1 | 8.89 |
| CHEMBL205846 | — | — | 1 | 8.74 |
| CHEMBL479432 | FEBRIFUGINE | — | 1 | 8.72 |
| CHEMBL380527 | — | — | 1 | 8.72 |
| CHEMBL204281 | — | — | 1 | 8.66 |
| CHEMBL425237 | — | — | 1 | 8.30 |
| CHEMBL205109 | — | — | 1 | 7.80 |
| CHEMBL382187 | — | — | 1 | 7.14 |
| CHEMBL383194 | — | — | 1 | 7.00 |
| CHEMBL382188 | — | — | 1 | 6.96 |
| CHEMBL204844 | — | — | 1 | 6.80 |
| CHEMBL382206 | — | — | 1 | 6.73 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381176 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL206613 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL426494 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL208004 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL208041 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL208509 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL205846 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL479432 | FEBRIFUGINE | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL380527 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL204281 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL425237 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL205109 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL382187 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL383194 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL382188 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL204844 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL382206 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 338.0 | nM | 6.47 |