Assay Detail
Functional
CHEMBL860693
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Cytotoxicity against rat hepatocytes
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of febrifugine analogues as potential antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.54 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208041 | — | — | 1 | 7.82 |
| CHEMBL208004 | — | — | 1 | 7.80 |
| CHEMBL204281 | — | — | 1 | 6.93 |
| CHEMBL380527 | — | — | 1 | 6.85 |
| CHEMBL479432 | FEBRIFUGINE | — | 1 | 6.77 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.72 |
| CHEMBL204844 | — | — | 1 | 5.16 |
| CHEMBL382206 | — | — | 1 | 5.01 |
| CHEMBL425237 | — | — | 1 | 4.89 |
| CHEMBL205109 | — | — | 1 | 4.82 |
| CHEMBL383194 | — | — | 1 | 4.80 |
| CHEMBL205846 | — | — | 1 | 4.77 |
| CHEMBL381176 | — | — | 1 | 4.77 |
| CHEMBL426494 | — | — | 1 | 4.75 |
| CHEMBL206613 | — | — | 1 | 4.72 |
| CHEMBL382187 | — | — | 1 | 4.72 |
| CHEMBL208509 | — | — | 1 | 4.72 |
| CHEMBL382188 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208041 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL208004 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL204281 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL380527 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL479432 | FEBRIFUGINE | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL204844 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL382206 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL425237 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL205109 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL383194 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL205846 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL381176 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL426494 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL206613 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL382187 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL208509 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL382188 | — | IC50 | = | 22000.0 | nM | 4.66 |