Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL860709

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of duck HBV transfected in primary duck hepatocytes
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Duck hepatitis B virus
Cell Type Hepatocyte
Confidence 1 — Organism
Curated By Intermediate

Target

Duck hepatitis B virus (CHEMBL613761)
Type ORGANISM
Organism Duck hepatitis B virus

Publication

Inhibition of hepatitis B virus (HBV) replication by pyrimidines bearing an acyclic moiety: effect on wild-type and mutant HBV.
Semaine W, Johar M, Tyrrell DL, Kumar R, Agrawal B.
J Med Chem (2006) 49 : 2049 -2054
PubMed 16539393 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 5.06 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL141 LAMIVUDINE 4.0 1 7.40
CHEMBL109792 1 6.40
CHEMBL278418 1 5.43
CHEMBL165179 1 5.41
CHEMBL206306 1 5.30
CHEMBL437312 1 4.69
CHEMBL206108 1 4.60
CHEMBL202912 1 4.51
CHEMBL17559 1 4.50
CHEMBL204000 1 4.44
CHEMBL381807 1 4.39
CHEMBL35179 1 4.37
CHEMBL203345 1 4.32
CHEMBL382589 1 -
CHEMBL204329 1 -
CHEMBL425224 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL141 LAMIVUDINE EC50 = 40.0 nM 7.40
CHEMBL109792 EC50 = 400.0 nM 6.40
CHEMBL278418 EC50 = 3700.0 nM 5.43
CHEMBL165179 EC50 = 3900.0 nM 5.41
CHEMBL206306 EC50 = 5000.0 nM 5.30
CHEMBL437312 EC50 = 20400.0 nM 4.69
CHEMBL206108 EC50 = 25000.0 nM 4.60
CHEMBL202912 EC50 = 30600.0 nM 4.51
CHEMBL17559 EC50 = 32000.0 nM 4.50
CHEMBL204000 EC50 = 36400.0 nM 4.44
CHEMBL381807 EC50 = 40900.0 nM 4.39
CHEMBL35179 EC50 = 43200.0 nM 4.37
CHEMBL203345 EC50 = 47600.0 nM 4.32
CHEMBL382589 EC50 > 53000.0 nM -
CHEMBL204329 EC50 > 49500.0 nM -
CHEMBL425224 EC50 > 47800.0 nM -