Assay Detail
Functional
CHEMBL860713
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Inhibition of HBV M204I mutant transfected in B1 cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | B1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inhibition of hepatitis B virus (HBV) replication by pyrimidines bearing an acyclic moiety: effect on wild-type and mutant HBV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.99 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1380 | ABACAVIR | 4.0 | 1 | 5.47 |
| CHEMBL109792 | — | — | 1 | 5.35 |
| CHEMBL278418 | — | — | 1 | 4.73 |
| CHEMBL165179 | — | — | 1 | 4.41 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1380 | ABACAVIR | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL109792 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL278418 | — | EC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL165179 | — | EC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL141 | LAMIVUDINE | EC50 | > | 44000.0 | nM | - |