Assay Detail
Functional
CHEMBL860813
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Eg5 by ATPase assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.48 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205786 | — | — | 1 | 6.98 |
| CHEMBL380367 | — | — | 1 | 6.51 |
| CHEMBL382364 | — | — | 1 | 6.50 |
| CHEMBL438073 | — | — | 1 | 6.46 |
| CHEMBL427386 | — | — | 1 | 6.22 |
| CHEMBL205441 | — | — | 1 | 6.21 |
| CHEMBL381794 | — | — | 1 | 6.19 |
| CHEMBL438800 | — | — | 1 | 6.09 |
| CHEMBL377073 | — | — | 1 | 5.90 |
| CHEMBL426857 | — | — | 1 | 5.75 |
| CHEMBL381599 | — | — | 1 | 5.64 |
| CHEMBL205928 | — | — | 1 | 5.60 |
| CHEMBL378389 | — | — | 1 | 5.56 |
| CHEMBL208309 | — | — | 1 | 5.51 |
| CHEMBL207601 | — | — | 1 | 5.46 |
| CHEMBL381062 | — | — | 1 | 5.33 |
| CHEMBL205863 | — | — | 1 | 5.33 |
| CHEMBL205297 | — | — | 1 | 5.27 |
| CHEMBL207292 | — | — | 1 | 5.26 |
| CHEMBL208145 | — | — | 1 | 5.08 |
| CHEMBL207148 | — | — | 1 | 5.05 |
| CHEMBL204278 | — | — | 1 | 4.96 |
| CHEMBL208226 | — | — | 1 | 4.89 |
| CHEMBL206258 | — | — | 1 | 4.89 |
| CHEMBL205278 | — | — | 1 | 4.88 |
| CHEMBL204411 | — | — | 1 | 4.84 |
| CHEMBL204372 | — | — | 1 | 4.79 |
| CHEMBL204371 | — | — | 1 | 4.75 |
| CHEMBL207867 | — | — | 1 | 4.74 |
| CHEMBL203681 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205786 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL380367 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL382364 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL438073 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL427386 | — | IC50 | = | 595.0 | nM | 6.22 |
| CHEMBL205441 | — | IC50 | = | 617.0 | nM | 6.21 |
| CHEMBL381794 | — | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL438800 | — | IC50 | = | 808.0 | nM | 6.09 |
| CHEMBL377073 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL426857 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL381599 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL205928 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL378389 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL208309 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL207601 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL381062 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL205863 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL205297 | — | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL207292 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL208145 | — | IC50 | = | 8330.0 | nM | 5.08 |
| CHEMBL207148 | — | IC50 | = | 8880.0 | nM | 5.05 |
| CHEMBL204278 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL206258 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL208226 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL205278 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL204411 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL204372 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL204371 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL207867 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL203681 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL207973 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL205099 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL205947 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL383198 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL206352 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL381553 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL203577 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL382217 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL381061 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL377098 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL205864 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL205495 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL382796 | — | IC50 | > | 25000.0 | nM | - |