Assay Detail

CHEMBL860817

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Functional

Antiproliferative activity against human PC3 cells

ChEMBL ↗

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Target

PC-3 (CHEMBL390) ↗

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Primary target PC-3

CHEMBL390

Anchored from Assay target.

Protein identity PC-3

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	PC-3
Confidence	1 — Organism
Curated By	Expert

Target

PC-3 (CHEMBL390) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.

Tarby CM, Kaltenbach RF, Huynh T, Pudzianowski A, Shen H, Ortega-Nanos M, Sheriff S, Newitt JA, McDonnell PA, Burford N, Fairchild CR, Vaccaro W, Chen Z, Borzilleri RM, Naglich J, Lombardo LJ, Gottardis M, Trainor GL, Roussell DL.
Bioorg Med Chem Lett (2006) 16 : 2095 -2100
PubMed 16458511 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.65	6.65

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL205786	—	—	1	6.65

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL205786	—	IC50	=	223.0	nM	6.65