Assay Detail
Functional
CHEMBL860878
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Antimalarial activity against Plasmodium falciparum Dd2
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.80 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204106 | — | — | 1 | 7.55 |
| CHEMBL204107 | — | — | 1 | 7.05 |
| CHEMBL206189 | — | — | 1 | 7.02 |
| CHEMBL205338 | FR-900098 | — | 1 | 6.75 |
| CHEMBL205339 | — | — | 1 | 6.70 |
| CHEMBL205053 | — | — | 1 | 6.66 |
| CHEMBL380142 | — | — | 1 | 6.57 |
| CHEMBL205052 | — | — | 1 | 6.46 |
| CHEMBL203125 | FOSMIDOMYCIN | 3.0 | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204106 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL204107 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL206189 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL205338 | FR-900098 | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL205339 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL205053 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL380142 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL205052 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL203125 | FOSMIDOMYCIN | IC50 | = | 360.0 | nM | 6.44 |