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Assay Detail

CHEMBL861000

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human LAPC4 cell line by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type LAPC4
Confidence 1 — Organism
Curated By Intermediate

Target

LAPC4 (CHEMBL613292)
Type CELL-LINE
Organism Homo sapiens

Publication

Benzoylphenylurea sulfur analogues with potent antitumor activity.
Hallur G, Jimeno A, Dalrymple S, Zhu T, Jung MK, Hidalgo M, Isaacs JT, Sukumar S, Hamel E, Khan SR.
J Med Chem (2006) 49 : 2357 -2360
PubMed 16570932 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 6.32 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL205487 1 7.30
CHEMBL203996 1 7.00
CHEMBL206073 1 6.70
CHEMBL306688 1 6.60
CHEMBL205622 1 6.22
CHEMBL208272 1 6.12
CHEMBL377936 1 5.40
CHEMBL203335 1 5.22
CHEMBL202742 1 -
CHEMBL204324 1 -
CHEMBL202947 1 -
CHEMBL203837 1 -
CHEMBL207795 1 -
CHEMBL203336 1 -
CHEMBL204572 1 -
CHEMBL381334 1 -
CHEMBL206036 1 -
CHEMBL206092 1 -
CHEMBL382800 1 -
CHEMBL203386 1 -
CHEMBL203387 1 -
CHEMBL206013 1 -
CHEMBL206014 1 -
CHEMBL383425 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL205487 IC50 = 50.0 nM 7.30
CHEMBL203996 IC50 = 100.0 nM 7.00
CHEMBL206073 IC50 = 200.0 nM 6.70
CHEMBL306688 IC50 = 250.0 nM 6.60
CHEMBL205622 IC50 = 600.0 nM 6.22
CHEMBL208272 IC50 = 750.0 nM 6.12
CHEMBL377936 IC50 = 4000.0 nM 5.40
CHEMBL203335 IC50 = 6000.0 nM 5.22
CHEMBL202742 IC50 - -
CHEMBL204324 IC50 - -
CHEMBL202947 IC50 - -
CHEMBL203837 IC50 - -
CHEMBL207795 IC50 - -
CHEMBL203336 IC50 - -
CHEMBL204572 IC50 - -
CHEMBL381334 IC50 - -
CHEMBL206036 IC50 - -
CHEMBL206092 IC50 - -
CHEMBL382800 IC50 - -
CHEMBL203386 IC50 - -
CHEMBL203387 IC50 - -
CHEMBL206013 IC50 - -
CHEMBL206014 IC50 - -
CHEMBL383425 IC50 - -