Assay Detail
Binding
CHEMBL861104
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Inhibition of strand transfer process of HIV1 integrase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.55 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210234 | — | — | 1 | 8.15 |
| CHEMBL379658 | — | — | 1 | 8.00 |
| CHEMBL378029 | — | — | 1 | 7.82 |
| CHEMBL210233 | — | — | 1 | 7.70 |
| CHEMBL377759 | — | — | 1 | 7.60 |
| CHEMBL209872 | — | — | 1 | 7.60 |
| CHEMBL199145 | — | — | 1 | 7.48 |
| CHEMBL209307 | — | — | 1 | 7.40 |
| CHEMBL426686 | — | — | 1 | 7.40 |
| CHEMBL441683 | — | — | 1 | 7.40 |
| CHEMBL208776 | — | — | 1 | 7.24 |
| CHEMBL379132 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210234 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL379658 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL378029 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL210233 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL377759 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL209872 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL199145 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL209307 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL426686 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL441683 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL208776 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL379132 | — | IC50 | = | 156.0 | nM | 6.81 |